FDA Warns Heartburn Drugs Interfere With Plavix

Common heartburn pills Prilosec and Nexium cut the blood-thinning effect of Sanofi-Aventis SA’s and Bristol-Myers Squibb Co’s heart drug Plavix, U.S. officials warned on Tuesday. The stomach drugs inhibit a key enzyme and reduce by almost half the anti-clotting effect of Plavix, which is taken by millions of people to reduce the risk of heart attacks and stroke, the Food and Drug Administration said.

The U.S. label for Plavix, known also as clopidogrel, is now being updated with new warnings on the use of AstraZeneca Plc’s Prilosec and other similar drugs, including Nexium, the agency said. Plavix is widely used with such so-called proton pump inhibitors, or PPIs, to reduce stomach acid and avoid gastric problems.

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